This New Research Raises Hopes to Halt Aging and Look Ever Young - chaprama | Insights from the world of Technology and Lifestyle


Friday, December 16, 2016

This New Research Raises Hopes to Halt Aging and Look Ever Young

We wish to stay younger for longer periods of time. Although Research is also active in this area since long no significant achievements were reported.  Now scientists at the Salk Institute, California,  moved a step closer and found a method that could pave for reverse aging in human and animal cells.

This New Research Raises Hopes to Halt Aging and Look Ever Young

Scientists used this method to treat mice suffering from a disease that causes premature aging (Progeria) and observed their life span increased by as much as 30 percent. When they used the same method on healthy mice they rejuvenated and some cells responded to injury much faster than other cells.

It is an established fact that turning on the four genes in humans known as Yamanaka factors restores human cells to state of embryo cells when observed in Petri dishes. Activated cells in this way are known as induced pluripotent stem cells and has the ability to convert in to any cell in the body. However, earler studies were faced with failures and when they used the same method in live animals they developed cancer.

In the present study, the scientists activated yamanaka factors only for a brief period of time. They used mice that suffer from progeria, a condition that cause them to age faster than normal. They genetically engineered mice so that they turn on Yamanaka factors only when treated with a particular antibiotic doxycycline.

The researchers carried  the treatment in progeria mice from the age of eight weeks.They administered the antibiotic for short period of time through out  the lifespan of mice.The results are encouraging. Mice treated in this way showed less curvature with age and also organ function improved.These mice also showed very less signs of ageing compared to untreated mouse.

Researchers also studied the antiageing treatment in old age mice.They  observed improved capacity of regeneration in some and in particular cells of muscles and pancreas responded swiftly to injury.They repeated the same treatment with human cells and found there was reversal of ageing as happened in progeria mice at the molecular level.

Researcher Juan Carlos Izpisua Belmonte, a professor in Salk Institute's Gene Expression laboratory in La Jolla, California, said that the study demonstrates that maturing is an exceptionally dynamic and plastic process and more responsive to therapauetic treatments.The researchers further hope this method provides a better understanding of the process of aging and similar approaches in future eliminate age-related diseases thereby improving the people's health and their lifespan.

The study was published in the journal cell.

The Research team explained their interventions in the video.

Source ; Live science

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